SIMULTANEOUS ADMINISTRATION OF EZH2 AND BET INHIBITORS INHIBITS PROLIFERATION AND CLONOGENIC ABILITY OF METASTATIC PROSTATE CANCER CELLS

Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells

Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC).However, after a certain period of responsiveness, ADT resistance occurs Correction Bit virtually in all patients and the disease progresses to lethal metastatic castration-resistant prostate cancer (mCRPC).Aberrant expression and function of the epigenetic

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Managing hyperemesis gravidarum: a multimodal challenge

Abstract Up to 90% of pregnant women experience nausea and vomiting.When prolonged or severe, this is known as hyperemesis gravidarum (HG), which can, in individual cases, be life threatening.In this article the aetiology, diagnosis and treatment strategies will be presented based on a selective literature review.Treatment strategies range from out

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Research Progress on the Chemical Constituents, Sensory Characteristics, and Biological Activities of Litsea pungens Hemsl.

Litsea pungens Hemsl., a type of deciduous or evergreen small tree or shrub, has significant value in fragrance, flavoring, and medicinal applications.However, the industry faces challenges such as low product technological content, limited processing models, and insufficient utilization in high-value processing.This article systematically reviews

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Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community

ABSTRACT The candidate phyla radiation (CPR) comprises a large monophyletic group of bacterial lineages known almost exclusively based on genomes obtained using cultivation-independent methods.Within the CPR, Gracilibacteria (BD1-5) are particularly poorly understood due to undersampling and the inherent fragmented nature of available genomes.Here,

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